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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1630425728210-V21W3SIEXH2APFKWSNX9/image.png Team - Richard Phillips, MD PhD PRINCIPAL INVESTIGATOR https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/3ceac737-4976-41d9-9291-70e02861b025/hannah.jpeg Team - Make it stand out HANNAH BUDNER Research Specialist BA, Hamilton College | 2023 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/e2e25b0b-d423-4be8-a324-2c09b5fc19b7/giovani.png Team - Make it stand out GIOVANI LUIZ GENESI, M.Sc. Bioinformatician / Research Specialist MSc, University of São Paulo | 2020 BSc, University of São Paulo | 2018 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/795eb92d-3a46-4e4c-adbd-4724c9655cd9/peter.jpg Team PETER BIBAWI Lab Manager / Research Specialist MSc, Rutgers University | 2015 BA, Cornell University | 2012 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/dc36c3ce-70cf-48d1-9155-466efe5e38f1/anna_k_cropped.png Team - Make it stand out ANNA KASPER Ph.D. Student (NGG) BSc, Rochester Institute of Technology | 2023 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/e2e7a682-a02f-4836-8dcc-f3b9ca954b76/ana_maria.jpg Team - Make it stand out ANA MARIA RODRIGUES, Ph.D. Postdoctoral Researcher PhD, University of São Paulo | 2023 MSc, Federal University of Espirito Santo | 2018 BSc, Federal University of Espirito Santo | 2016 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/94296aa5-c99b-4bd6-9dbe-a56448cc4875/aurelie.png Team AURELIE VANDERLINDEN DIBEKEME, Ph.D. Postdoctoral Researcher PhD, University of Sheffield MSc, University of Sheffield BSc, University of Sheffield https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/8c7d8edb-925e-441b-98a9-420efc717d32/hayley_lenhard.jpg Team - Make it stand out HAYLEY LENHARD Rotation Student (NGG) BA, Colgate University | 2024 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/2c3cf74b-cc91-484f-9182-1cccbe9a7802/mariam_babajide.jpg Team - Make it stand out FUNMI MARIAM BABAJIDE Research Specialist BSc, University of Houston | 2024 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/53a6d2d2-6557-473c-8185-4e76823c5b63/kaisha+garvin-darby.jpeg Team - Make it stand out KAISHA GARVIN-DARBY B.A. Candidate for Psychology Pennsylvania State University | Class of 2024 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/ea2f26d2-4c86-4350-810e-2a0ee43ca5a6/nana+kusi.png Team NANA KUSI B.A. Candidate for Computational Biology and Genomics Washington University in St. Louis | Class of 2022 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/3bd21532-ceff-4136-8539-c954bcd14b7e/akin.jpg Team AKINKUNMI ADIO B.A. Candidate for Neuroscience University of Pennsylvania | Class of 2025 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/5970becb-15fd-40f2-a329-ab3f9b782015/praneet.jpg Team PRANEET GUNDEPUDI B.A. Candidate for Neuroscience, Minor study in Chemistry and Healthcare Management University of Pennsylvania | Class of 2024 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/21eeefb6-609b-4e8f-9eaf-fae171f455b2/dalal+azzam.png Team DALAL AZZAM B.A. Candidate for Biochemistry and Neuroscience University of North Carolina in Chapel Hill | Class of 2022 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/3c5a81aa-7f88-49ec-9f74-163d87024ea4/Bismark.jpg Team BISMARK APPIAH, Ph.D. Postdoctoral Researcher https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/8338534b-071e-4f18-9a81-f390dfa28c2c/minghui.jpg Team MINGHUI YUE, Ph.D. Postdoctoral Researcher https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/b75142eb-1fde-4d2c-8e49-4ce2bd708311/james.jpg Team JAMES INNES, Ph.D. Postdoctoral Researcher https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/8bd901af-d64c-4105-b32f-0bc5b925d4d6/jonathan.jpg Team JONATHAN LANG MD, PhD Candidate, University of Pennsylvania | Class of 2022 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1608075738837-GO1EUJ6N2VH56KLJ3QR3/blue.png Team https://www.thephillipslab.com/contact daily 0.75 2020-12-23 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1590686714927-FI5PF91RQG9UDM9GRVFI/Our+Location.png Contact https://www.thephillipslab.com/research daily 0.75 2020-12-17 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1607983560925-31TGN97C9SSCHF3RXXGC/MI-2crystalhighrescolors.png Research - Novel glioma therapeutics Identifying therapeutic targets in brain cancer has remained a challenge with not a single targeted therapy showing consistent efficacy. Drawing from our mechanistic work to understand how epigenetic regulation is perturbed in brain cancer, we are interested in identifying epigenetic pathways which can be targeted in brain cancer. Additionally, we use unbiased approaches including high-throughput genetic and small molecule screens in patient-derived glioma cells, organoids and genetically engineered mouse models to identify pathways which are specifically required in brain cancer cells. Ultimately, our goal is to rapidly translate our findings into human clinical trials within the Brain Tumor Center here at the University of Pennsylvania. https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1607965333366-C014GGZTVY90MEIVR6DO/epigeneitic+regulation+v3.png Research - Epigenomic reprogramming in glioma Coordinated epigenetic regulation enables cells to adopt specific gene expression programs to orchestrate normal differentiation and maintain cell fate. Gliomas are the most common type of brain cancer and exome-sequencing data has identified mutations in epigenetic regulators as a major driver of these tumors. However, it remains incompletely understood how these epigenetic drivers rewire the chromatin landscape and how this epigenetic dysregulation alters cellular phenotypes such as differentiation and immune evasion. In the Phillips Lab, we employ a number of cutting-edge techniques – from the development of forward genetics tools (i.e. CRISPR-Cas9 screening technology), epigenomic profiling, using neural stem cell models, and patient-derived models of glioma – to elucidate how epigenetic mechanisms contribute to gliomagenesis. Our long term research goal is to understand the how epigenetic pathways are rewired in brain cancer during tumorigenesis, therapy, and evasion of immunity. https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1608075691705-HHIA8SXFHCD90PGKE5T8/blue.png Research https://www.thephillipslab.com/partners-gallery-mobile daily 0.75 2020-11-30 https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983806084-86RU2HVTV3TLX6Z2TTEZ/Penn+Medicine+%281%29.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983806084-86RU2HVTV3TLX6Z2TTEZ/Penn+Medicine+%281%29.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983382387-CPES508CCSR41TN4IU3Z/Epigenetics+Institute.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983384095-QFOZ0EO19UOZ5QR95Q2B/Penn+Medicine.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983380315-UJJH7X5HQDMNFZYK7OOX/Abramson+Cancer+Center.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983141219-S11VHDCMGHZTWU143IRL/Abramson+Cancer+Center.png Partners Gallery Mobile https://images.squarespace-cdn.com/content/v1/5ecd6d52e7531e275003bb83/1591983572068-MD1X7WDSEZHMVIXKOV2A/CHOPA+%283%29.png Partners Gallery Mobile https://www.thephillipslab.com/papers-publications daily 0.75 2025-03-21 https://www.thephillipslab.com/papers-publications/specific-cprc1-complexes-are-co-opted-to-mediate-oncogenic-gene-repression-in-diffuse-midline-glioma monthly 0.5 2025-03-21 https://www.thephillipslab.com/papers-publications/a-chemical-strategy-toward-novel-brain-penetrant-ezh2-inhibitors monthly 0.5 2022-12-08 https://www.thephillipslab.com/papers-publications/epigenomic-reprogramming-as-a-driver-of-malignant-glioma monthly 0.5 2022-12-08 https://www.thephillipslab.com/papers-publications/target-identification-reveals-lanosterol-synthase-as-a-vulnerability-in-glioma monthly 0.5 2022-12-08 https://www.thephillipslab.com/papers-publications/management-of-late-extraneural-recurrence-of-medulloblastoma-without-high-dose-chemotherapy monthly 0.5 2022-12-08 https://www.thephillipslab.com/sidebar daily 0.75 2020-06-14